Design, synthesis, and anticancer activity of novel 4,6-dimorpholinyl-1,3,5-triazine compounds

Abstract A series of novel 4,6-dimorpholinyl-1,3,5-triazine derivatives 6a–6r were obtained through N -substitution and Claisen-Schmidt condensation. 1 H NMR, 13 C mass spectrometry used to characterize the molecular structures derivatives. The in vitro antiproliferation activity was evaluated using MTT assay against SW620 (human colon cancer cells), A549 nonsmall cell lung HeLa cervical MCF-7 breast cells). Compound 6o bearing a pyridyl group exhibited good cytotoxicity four cells, with IC 50 values 8.71, 9.55, 15.67, 21.77 μM, sequentially. In addition, compound 6a showed some selectivity SW620.